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Approximately 75-89% of the peer–reviewed published literature are thought to be non-reproducible. A need exists to better address the problem of irreproducibility of research data so that contradictory, null and negative findings can be disclosed in an unbiased, non-judgemental, yet scientifically plausible manner. Journal of Controversies in Biomedical Research (JCBMR; www.jcbmr.com) is an attempt to address the ‘reproducibility crisis’ in biomedical research. JCBMR is an online-only open access journal that will publish basic science or clinical research articles that meet any of the following criteria: a) original articles that demonstrate biologically plausible negative, neutral or contentious findings; b) original articles that challenge previously published results in peer-reviewed journals; c) original articles that show effects of compounds on disease models (either in vitro or in vivo) are contradictory to the expected outcome; d) review articles that critically evaluate and challenge established norms and offer possible solutions to the problem; e) any manuscript that will assist the scientific community to re-think and re–evaluate the established norm.
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